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Tim Lefever
lefevert@uncw.edu
PROFESSIONAL EXPERIENCE
University of North Carolina at Wilmington,
Psychology Department Wilmington, NC
Part Time Faculty-August
2010-current
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Drugs and Behavior-Psychology 245
Research
Assistant/Technician Behavioral Pharmacology Laboratory- July
2007-current
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Conducts research investigating short-term memory using
olfactory stimuli in rats, utilizing both delayed match and
non-match-to-sample paradigms, in the research laboratory of Mark Galizio,
PhD.
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Prepares and administered drugs for experiments (intraperitoneal).
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Creates and maintains olfactory stimuli for experiments.
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Developed a modified operant chamber apparatus to conduct
delayed match and non-match-to-sample experiments.
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Built an automated olfactory operant chamber system and wrote
the programs necessary to run delayed match and non-match-to-sample
experiments, simple discrimination, and transitive inference using Med-PC
software.
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Analyzes data using Microsoft Excel, Graphpad Prism, SPSS and
Sigma plot software.
Full Time Animal Caretaker-November
2009-current
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Responsibilities include making certain that the laboratory
meets the guidelines set by IACUC, meeting the needs of the laboratory
animals (rats, mice and pigeons) by providing fresh food, water and bedding,
determining the best method for cleaning cages, monitoring health concerns
and delegating responsibilities to undergraduate and graduate students.
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Teach new students coming into the lab proper ways of handling and caring
for the animals.
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Maintain the health of animals, determining when to call a veterinarian and
treating minor injuries appropriately.
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Maintain inventory of supplies and determine the appropriate bedding and
diets that should be used with each group of animals.
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Order new animals as needed and maintain a database monitoring the protocols
of each research project occurring in the laboratory.
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Euthanize animals when necessary as stated by IACUC guidelines.
Temple University School of Pharmacy, Department of
Pharmaceutical Sciences
Philadelphia, PA- May 2004-July 2007
Research Coordinator for the Behavioral
Pharmacology Laboratory
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Singly responsible for the planning, coordination, and
execution of daily research activities in the NIH-funded research laboratory
of Ellen Walker, PhD.
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Maintained laboratory supplies and equipment/animal ordering
as well as budgets and grant cost center accounts.
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Modified and created behavioral experiments programs for the
laboratory including autoshaping, drug discrimination, progressive ratio and
self-administration using Med-Associate Programming Software and equipment.
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Coordinated laboratory meetings, schedules and training of
other laboratory staff, professional and undergraduate staff.
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Prepared drugs for experiments, and administered rodent
(subcutaneous, intraperitoneal, and intramuscular) and pigeon injections
(intramuscular).
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Feeding and care for mice, rats and pigeons.
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Research projects included the investigation of the role of
the serotonin2C receptor in the behavioral effects of drugs including drug
discrimination, conditioned taste aversion, feeding, progressive ratio,
autoshaping, and self-administration protocols in rats, mice, and pigeons.
In addition, research projects included the investigation of opioid
antagonist combinations in antinociception assays in mice and rats.
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Analyzed data using both Graph Pad Prism and Microsoft Excel
programs.
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Prepared, presented, and published abstracts, posters, and
manuscripts.
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Assisted in writing, editing and referencing grant proposals.
University of Wisconsin Eau Claire, Psychology
Department Eau Claire, WI- November 2002 to May 2004
Behavioral Laboratory Worker
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Carried out behavioral experiments with rats to observe the
effects of centrally administered peptides effects on food intake and
motivation to work for food, through discrimination, progressive ratio, and
food intake studies using Med-Associates operant equipment and computer
systems, in the laboratory of Dave Jewett, PhD.
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Responsible for animal care: feeding, cleaning cages and
upkeep of operant chambers and other equipment, as well as data collection
and processing.
EDUCATION
Master of Arts, Experimental Psychology –
University of North Carolina at Wilmington, 2007-2009.
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Completed coursework for the requirements of the Master of
Arts Degree in Experimental Psychology, 12-10-2009.
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Completed thesis: “EFFECTS OF OLANZAPINE ON OLFACTORY
DELAYED-MATCHING-TO-SAMPLE IN RATS.”
Bachelor of Science, Psychology –
University of Wisconsin Eau Claire, 5-22-2004
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Completed coursework for Behavior Analysis Emphasis within the
completion of the requirements for a psychology major.
AWARDS
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Sigma Xi Fellowship awarded for purchase of equipment
for thesis, 2008.
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Brauer Fellowship awarded for purchase of equipment for
thesis, 2007.
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Scholarships awarded from Med-Associates Inc. to attend
the seminar: Short Courses in Neuroscience; classes on Med-PC programming
and drug self-administration. 2006.
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First place for graduate level poster competition at
the Mid-Atlantic Pharmacology Society meeting, 2006.
VOLUNTEER ACTIVITIES
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Brain Awareness Week: The Dana Alliance for Brain Initiatives
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Franklin Institute, Philadelphia, PA. 2005-2007.
SEMINARS AND COURSES
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NIDA Frontiers in Addiction, Seminar, Atlanta, GA. 2006.
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Short Courses in Neuroscience: Med-PC programming and drug
self-administration. St. Albans, VT, 2006.
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NIDA Frontiers in Addiction, Seminar, Washington DC. 2005.
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NIDA Frontiers in Addiction, Seminar, San Diego, CA. 2004.
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NIDA Frontiers in Addiction, Seminar, New Orleans, LA. 2003.
MEMBERSHIPS
Society for Neuroscience- since 2003
Society for the Stimulus Properties of Drugs-
since 2004
Philadelphia Chapter of Society for Neuroscience –
2005-2007
The American Society for Pharmacology and
Experimental Therapeutics (ASPET) - 2006-2008
- Behavioral Pharmacology Division of
ASPET - 2006-2008
- Mid-Atlantic Pharmacology Society
Chapter of ASPET - 2006-2008
PUBLICATIONS
Lefever TW. Titrating delayed non-match-to-sample using olfactory stimuli in
rats. In Progress.
Lefever TW and Walker EA. Serotonin neuromodulation of feeding behavior in
young, adolescent, and adult rats. In Progress.
Lefever TW and Walker EA. Effects of 5-HT2C agonists and
antagonists in mice trained to discriminate MK212. In Progress.
Ward SJ, Lefever TW, Rawls SM, Whiteside GT, Walker EA.
Age-dependent effects of the cannabinoid CB1 antagonist SR141716A on
food intake, body weight change, and pruritus in rats.
J Psychopharmacology.
2009 July:206(1):155-165.
Ward SJ, Lefever TW, Jackson C, Tallarida RJ, Walker
EA. Effects of a CB1 receptor antagonist and 5-HT2C receptor agonist alone
and in combination on motivation for palatable food: A dose-addition
analysis study in mice. J Pharmacol Exp Ther. 2008 Feb.:
325(2):567-576.
Jewett DC, Lefever TW,
Flashinski DP, Koffarnus MN, Cameron CR, Hehli DJ, Grace MK, Levine AS.
Intraparaventricular neuropeptideYand ghrelin induce learned behaviors that
report food deprivation in rats. Neuroreport. 2006
May;17(7):733-737.
Walker EA,
Kohut SJ,
Hass RW,
Brown EK Jr,
Prabandham A,
Lefever T. Selective and nonselective serotonin antagonists block the
aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in
mice.
Neuropharmacology. 2005 Dec;49(8):1210-1219.
POSTER PRESENTATIONS
T.W. Lefever,
L. Bullard, A. Ward, & M. Galizio. TITRATING MATCH/NON-MATCH-TO-SAMPLE,
USING OLFACTORY STIMULI IN RATS. Presented at the annual Society for
Neuroscience Meeting. Washington D.C., 2009.
T.W. Lefever,
L. Bullard, A. Ward, & M. Galizio. EFFECTS OF DRUGS ON DELAYED MATCH AND
NON-MATCH-TO-SAMPLE PERFORMANCE USING OLFACTORY STIMULI IN RATS. Presented
at the Darwin’s Legacy Conference. Wimington, NC, 2009.
T. W.
Lefever, L. Bullard, L. Lazarowski, & M. Galizio. DELAYED MATCH AND
NON-MATCH-TO-SAMPLE WITH OLFACTORY STIMULI IN RATS. Presented at the annual
Society for Neuroscience Meeting. Washington D.C., 2008.
T.W. Lefever
& E.A. Walker. ENHANCED DISCRIMINATIVE STIMULUS EFFECTS OF MK212 AND
METHYSAERGIDE MALEATE. Presented at Society for the Stimulus Properties of
Drugs satellite meeting, Washington D.C., 2008.
T.W. Lefever
& E.A. Walker. SEROTONIN NEUROMODULATION OF FEEDING BEHAVIOR IN YOUNG,
ADOLESCENT, AND ADULT RATS. Presented at Mid-Atlantic Pharmacology Society
meeting. King of Prussia, PA, 2006.
E.A. Walker
& T.W. Lefever. DISCRIMINATIVE STIMULUS EFFECTS OF PROPOSED 5-HT2C INVERSE
AGONISTS MIANSERIN AND SB200,646 IN MICE. Presented at Society for the
Stimulus Properties of Drugs satellite meeting, Atlanta, GA, 2006.
T.W. Lefever,
L. Gilbert, S.J. Ward, E.A. Walker. SEROTONIN NEUROMODULATION OF FEEDING
BEHAVIOR IN YOUNG, ADOLESCENT, AND ADULT RATS. Program No. 62.1. 2006
Abstract Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2006. Presented at annual Society for Neuroscience meeting.
Atlanta, GA, 2006.
T.W. Lefever,
M. Farrell, C.A. Santos, E.A. Walker. DISCRIMINATIVE STIMULUS EFFECTS OF
METHYSERGIDE MALEATE. Presented at Philadelphia Chapter of Society for
Neuroscience, Philadelphia, PA, 2006.
E.A. Walker
& T.W. Lefever. DISCRIMINATIVE STIMULUS EFFECTS OF PROPOSED 5-HT2C INVERSE
AGONISTS MIANSERIN AND SB200,646 IN MICE. FASEB: American Society for
Pharmacology and Experimental Therapeutics, San Francisco, CA, April 2006.
T.W. Lefever
& E.A. Walker. EFFECTS OF 5-HT2C AGONISTS & ANTAGONISTS IN MICE
TRAINED TO DISCRIMINATE MK212. Presented at Philadelphia Chapter of Society
for Neuroscience, Philadelphia, PA, 2005.
T.W. Lefever,
M. Farrell, C.A. Santos, E.A. Walker. DISCRIMINATIVE STIMULUS EFFECTS OF
METHYSERGIDE MALEATE. Program No. 567.6. 2005 Abstract Viewer/Itinerary
Planner. Washington, DC: Society for Neuroscience, 2005. Presented at
annual Society for Neuroscience meeting. Washington D.C., 2005.
T.W. Lefever
& E.A. Walker. EFFECTS OF 5-HT2C AGONISTS & ANTAGONISTS IN MICE
TRAINED TO DISCRIMINATE MK212. Presented at European Behavioral
Pharmacology Society meeting. Barcelona, Spain, 2005.
D.C. Jewett,
D.J. Hehli, S.J. Weis, B.J. Stefonik, T.W. Lefever, C.R. Cameron, M.N.
Koffarnus, R.R. Rozeske II, M.K. Grace, A.S. Levine. NEUROPEPTIDE Y AND
GHRELIN PRODUCE DISCRIMINATIVE STIMULUS EFFECTS SIMILAR TO 22 HOURS FOOD
DEPRIVATION. Program No. 194.12. 2004 Abstract Viewer/Itinerary Planner.
Washington, DC: Society for Neuroscience, 2004. Presented at annual Society
for Neuroscience meeting. San Diego, CA, 2004.
C.R.
Cameron, J.J. Majeres, S.M. Cook, L.M. Nackers, E. Alden-Anderson, L.M.
Eveland, A.R. Beaudry, T.W. Lefever, M.K. Grace, A.S. Levine, D.C. Jewett.
AGOUTI-RELATED PEPTIDE DOES NOT INCREASE BREAK POINT UNDER A PROGRESSIVE
RATIO 1 REINFORCEMENT SCHEDULE IN RATS. Program No. 317.6. 2004 Abstract
Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience,
2004. Presented at annual Society for Neuroscience meeting. San Diego, CA,
2004.
D.C. Jewett,
T.W. Lefever, C.R. Cameron, D.P. Flashinski, M.N. Koffarnus, A.R. Beaudry,
K.M. Masters, M.K. Grace, A.S. Levine. GHRELIN INCREASES BREAK POINT UNDER A
PROGRESSIVE RATIO 1 REINFORCEMENT SCHEDULE IN RATS. Program No. 283.15.
2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for
Neuroscience, 2003. Presented at annual Society for Neuroscience meeting.
New Orleans, LA, 2003.
REFERENCES
Mark J. Galizio, PhD
Psychology Department Chair and Professor
University of North Carolina at Wilmington
601 South College Road.
Wilmington, NC 28403
Phone: (910)962-3813
Fax: (910)962-7010
e-mail: galizio@uncw.edu
Ellen A. Walker, PhD
Associate Professor of Pharmacodynamics
Temple University School of Pharmacy
3307 North Broad Street
Philadelphia, PA 19140
Phone: (215)707-6770
Fax: (215)707-3678
e-mail:
ellen.walker@temple.edu
Sara J. Ward, PhD
Research Assistant Professor
Temple University School of Pharmacy
3307 North Broad Street
Philadelphia, PA 19140
Phone: (215)707-1005
Fax: (215)707-3678
e-mail:
sara.ward@temple.edu
David C. Jewett, PhD
Professor of Psychology
University of Wisconsin Eau Claire
105 Garfield Ave
Eau Claire, WI 54702
Phone: (715) 836-2429
Fax: (715) 836-2214
e-mail:
jewettd@uwec.edu
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