Jessika Laurore
|
Department of Chemistry and
Biochemistry |
Contact Info: jdl5456@uncw.edu |
Mid-way
through this summer I began my DIS in Dr. Varadarajan lab. My project this
semester is focused on the synthesis of quorum signaling molecules that can
interfere with bacterial communication. Quorum sensing is the mechanism in
which bacterial cells communicate. Bacteria are able to communicate with each
other through these signaling molecules. Gram negative bacteria often have an
acylated homoserine lactone for quorum signaling. This homoserine lactone is
the main component of this type of bacteria. While the acyl side chain can
differ in the number of carbons, its saturation level, and its functional
groups. My desire this semester is to synthesize different signaling
molecules that will interfere with bacterial communication. These molecules
will all have the homoserine lactone component, but the acyl side chain will
vary. The study of these types of molecules could help in the designs of
better drugs that can fight off gram-negative bacteria infection. This
project already is helping me think more abstractly in applying classroom
knowledge to real-life experience. I am thankful to Dr. Varadarajan, and the
Department of Chemistry and Biochemistry, for allowing me to do intriguing
research as an undergraduate student. Also thank you to the Department of
Chemistry and Biochemistry for selecting me to participate in the
GlaxoSmithKline Women in Science Mentoring Program, which will allow me to
have a scientist in the industry advise me and allow me to learn for her own
experiences. I am excited for what is to come this semester with this program
and my research.
Jessika Laurore
|
Department of Chemistry and
Biochemistry |
Contact Info: jdl5456@uncw.edu |