Selected Publications

Home Dr. Varadarajan Research Interests Students Department of Chemistry and Biochemistry UNCW

Kelly, C. B.; Hill, H.; Bartolotti, L., and Varadarajan S. Molecular Dynamics of d(CGCGAATTCGCG)2 Complexed with Netropsin and Its Minor Groove Methylating Analog, Me-lex, Using Explicit and Implicit Water Models J. of Molec. Structure – Theochem, 894, 50-58 (2009). Bobola, M. S.; Varadarajan, S., Smith, N. W., Goff, R. D., Kolstoe, D. D., Blank, A., Gold, B., and Silber, J. R., Characterization of human glioma cell sensitivity to the sequence-specific alkylator methyl-lexitropsin, Clinical Cancer Research, 13(2), 612-620 (2007). Monti, P.; Iannone, R.; Campomenosi, P.; Ciribilli, Y.; Varadarajan, S.; Shah, D.; Menichini, P.; Gold, B., and Fronza, G. Influences of nucleotide and base excision repair defects on the lethality and mutagenicity induced by Me-lex, a sequence selective N3-adenine methylating agent, Biochemistry, 43, 5592-5599 (2004). Blank, A.; Bobola, M. S.; Gold, B.; Varadarajan, S.; Kolstoe, D. D.; Meade, E. H.; Rabinovitch, P. S.; Loeb, L. A.; Silber, J. R., The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function, DNA Repair, 3, 629-638 (2004). Varadarajan, S.; Shah, D.; Dande, P.; Settles, S., Chen, F-X., Fronza, G., and Gold, B. DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters, Biochemistry 42, 14318-14327 (2003). Drake, J., Kanski, J., Varadarajan, S., Tsoras, M., and Butterfield, D. A. Elevation of Brain Glutathione by gamma-glutamylcysteine ethyl ester protects against peroxynitrite-induced oxidative stress, J. Neuroscience Res. 68, 776-784 (2002). Varadarajan, S., Kanski, J., Aksenova, M., Lauderback, C., and Butterfield, D. A. The mechanism of oxidative stress and neurotoxicity of Alzheimer’s Abeta(1-42) is different from that of Abeta(25-35), J. Am. Chem. Soc., 123, 5625-5631 (2001). Kanski, J., Varadarajan, S., Aksenova, M., and Butterfield, D. A. Role of glycine-33 and methionine-35 in Alzheimer’s amyloid beta-peptide 1-42- associated oxidative stress and neurotoxicity, Biochim. Biophys. Acta, 1586, 190-198 (2001). Yatin, S. M., Yatin, M., Varadarajan, S., Ain, K. B., and Butterfield, D. A. Role of spermine and amyloid beta-peptide(1-42) associated free radical induced neurotoxicity, J. Neurosci. Res., 63, 395-401, (2001). Varadarajan, S., Yatin, S., and Butterfield, D. A. Alzheimer’s amyloid beta-peptide (1-42) fibrils are not always toxic, Alzheimer’s Reports, 3, 71-76 (2000). Wondrak, G., Varadarajan, S., Butterfield, D. A., and Jacobson, M. K. Formation of a Protein-Bound pyrazinium free radical cation during glycation of histone H1, Free Radical Biology and Medicine, 29, 557-567 (2000). Yatin, S. M., Varadarajan, S., and Butterfield, D. A. Vitamin E prevents Alzheimer’s amyloid beta-peptide (1-42)-induced protein oxidation and reactive oxygen species formation, Journal of Alzheimer’s Disease, 2, 123-131 (2000). Varadarajan, S., Yatin, S., Aksenova, M., and Butterfield, D. A. Review: Alzheimer’s Amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity, J. Struct. Biol., 130, 184-208 (2000). Varadarajan, S., Yatin, S., Kanski, J., Jahanshahi, F., and Butterfield, D. A. (1999) Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress, Brain Res. Bull. 50, 133-141. Butterfield, D. A., Yatin, S., Varadarajan, S., and Koppal, T. Amyloid beta-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer’s disease, Meth. Enzymol. 309, 746-768 (1999). Maslak, P., Varadarajan, S., and Burkey, J. D. (1999) Synthesis, structure, and nucleophile-induced rearrangements of spiroketones, J. Org. Chem. 64, 8201-8209.